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[目的]观测精准护理干预措施在改善肾肿瘤患者术后炎症因子及免疫状态的效果.[方法]选取2015年10月1日至2016年12月1日在本院进行肾脏肿瘤切除手术患者90例作为研究对象,按随机数法分成两组,各37例.对照组实施常规护理,观察组在常规护理基础上应用精准护理干预措施,比较分析两组护理前、后炎症因子[白细胞介素-1(interleukin-1,IL-1),血清肿瘤坏死因子(TNF-α)]、免疫状态以及肾功能指标水平.[结果]护理干预前,两组 IL-1、TNF-α水平差异无统计学意义(P>0.05);实施护理后,两组IL-1、TNF-α指标均较本组治疗前降低,且观察组下降趋势更明显,差异有统计学意义(P<0.05);护理后观察组的CD4+、CD3+、CD8+、IgA、IgG、IgM水平均明显高于对照组,差异有统计学意义(P0.05).After treatment, the levels of IL-1 and TNF-α in the two groups were lower than those before treatment, and the descending trend of the observation group was more obvious than that of control group (P<0.05).The levels of CD4+, CD3+, CD8+, IgA, IgG and IgM in the observation group were significantly higher than those in the control group (P<0.05).[Conclusion] The precise nursing intervention can effectively reduce the inflammatory reaction in the patients after renal surgery, improve the function of the immune system and renal function, and promote the prognosis of patients with rehabilitation and quality of life.It is worthwhile to put precise nursing intervention into clinical application.