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目的探讨乳腺恶性肿瘤的临床病理特征。方法回顾性分析127例乳腺恶性肿瘤的临床特点、病理特征及免疫组化表现。结果乳腺恶性肿瘤占乳腺肿瘤的10.36%,良恶性比例为8.65:1,发病率在10年间由4.72%上升至11.81%,呈逐年升高趋势;发病高峰年龄为40～49岁(36.22%);病灶均为单侧、单个包块,左侧多于右侧,左右两侧比为1.15:1。肿瘤直径以2～5cm最多见(54.33%)。病理类型以浸润性导管癌(非特殊性)为最多见(81.10%)。可评估的96例中有65例(67.71%)有不同程度的淋巴结转移。免疫组化ER、PR和c-erbB-2阳性表达率分别为56.00%、53.33%和56.00%;Ki67阳性表达率100.0%增殖指数平均为21%;p53阳性表达率为55.00%。结论乳腺恶性肿瘤是危害女性生命健康的主要肿瘤,预后与患者年龄、病理分型、腋窝淋巴结转移情况及免疫组化等有密切关系,早诊断和早治疗可以提高生存率。
Objective To investigate the clinicopathological features of breast cancer. Methods Retrospective analysis of 127 cases of breast cancer clinical features, pathological features and immunohistochemical findings. Results The incidence of breast cancer was 10.36% and the rate of benign and malignant tumors was 8.65: 1. The incidence rate of breast cancer increased from 4.72% to 11.81% in 10 years, showing an increasing trend year by year. The peak age of onset was 40-49 years (36.22%), ; Lesions were unilateral, single mass, more than the right side of the left, left and right ratio of 1.15: 1. Tumor diameter to 2 ~ 5cm most see (54.33%). Pathological type of invasive ductal carcinoma (non-specific) is the most common (81.10%). Among the 96 evaluable cases, 65 (67.71%) had different degrees of lymph node metastasis. The positive rates of ER, PR and c-erbB-2 in immunohistochemistry were 56.00%, 53.33% and 56.00%, respectively. The average proliferation index of Ki67 positive was 100.0% and the positive rate of p53 was 55.00%. Conclusions Breast malignant tumor is the main tumor that endangers women’s life and health. The prognosis is closely related to patient’s age, pathological type, axillary lymph node metastasis and immunohistochemistry. Early diagnosis and early treatment can improve the survival rate.