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在治疗先天陛免疫功能不全症,重症感染,难治性血小板减少性紫癜(ITP)等自身免疫性疾病,难治性肾病综合征,川崎病,常见变异免疫缺陷症等疾病使用免疫球蛋白制剂时,是否会有感染AIDS 的危险,是一个很大的问题。Webster 等人1986年报道2例(一为20岁女性,一为33岁男性)多发性γ-球蛋白缺乏症。每2周静脉注射Sandog lobulin200mg/kg。从这2例病例中分离出类似AIDS 病毒的逆转录病毒。而Tedder 等人1985年报道,16例使用HTLV—Ⅲ/LAV抗体阳性血浆制成的治疗乙型肝炎的免疫球蛋白(HBIG),在注射后追踪调查了6个月,结果AIDS 病毒抗体全部阴性。Bremard—Qury 等人1986年报道:注射免疫球蛋白的680例中,均未出现AIDS 或者与
Immunoglobulin preparations are used in the treatment of autoimmune diseases such as innate immune deficiency syndrome, severe infection and idiopathic thrombocytopenic purpura (ITP), refractory nephrotic syndrome, Kawasaki disease, and common variant immunodeficiency diseases Whether or not there is a danger of contracting AIDS is a big problem. Webster et al. Reported in 1986 two cases of multiple γ-globulin deficiency in a 20-year-old female and a 33-year-old male. Sandog lobulin 200 mg / kg was injected intravenously every 2 weeks. A retrovirus similar to the AIDS virus was isolated from these 2 cases. Tedder et al reported in 1985 that 16 cases of hepatitis B virus immunoglobulin (HBIG) treated with HTLV-III / LAV antibody-positive plasma were followed up for 6 months after injection. As a result, all of the AIDS virus antibodies were negative . Bremard-Qury et al reported in 1986: None of the 680 immunoglobulin injections developed AIDS or