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对连续使用2周期克罗米芬(CC)促排卵治疗出现黄体早熟的22例患多囊卵巢综合征(PCOS)的不育妇女进行了前瞻性随机对照研究。 黄体早熟的标准为:在hCG使用前血清孕激素值P>4.8 nmol/L。将患者随机分成2组:A组10例单用FSH,B组12例联合应用GnRH-a和FSH。无论末次月经结束多长时间,经血清hCG测定排除妊娠,A组即开始肌肉注射FSH,每4～5天增加一支。B组皮下注射0.1 mg/d GnRH-a直至加用hCG,在注射0.1 mg/d GnRH-a 4～5天后加用FSH,方法和剂量同A组。自肌注FSH第3天开始通过血清雌激素(E_2)测定和阴道超声观察两组的卵泡发育。2组自肌注FSH第3天开始每天测定血清P的水平。当卵泡的直径≥
A prospective, randomized, controlled study of 22 infertile women with polycystic ovary syndrome (PCOS) who developed progesterone in two consecutive cycles of clomiphene (CC) ovulation induction was performed. Prolapse of the standard luteal phase: serum hCG before use of serum progesterone value P> 4.8 nmol / L. The patients were randomly divided into two groups: group A 10 cases of FSH alone, group B 12 cases of combined use of GnRH-a and FSH. No matter how long the end of the last menstrual period, the serum hCG determination excluded pregnancy, group A began intramuscular injection of FSH, an increase of every 4 to 5 days. In group B, 0.1 mg / d GnRH-a was subcutaneously injected until hCG was added, and FSH was added 4 to 5 days after injection of 0.1 mg / d GnRH-a. The method and dose were the same as group A. From the third day after intramuscular injection of FSH, follicular development in both groups was observed by serum estrogen (E2) assay and vaginal ultrasound. The levels of serum P in the two groups were measured daily on the third day after intramuscular injection of FSH. When the follicle diameter ≥