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近十多年来,有关胎儿胎盘功能研究进展较多,对高危妊娠之处理及降低围产期死亡起了一定作用。今就其近况加以介绍。一、雌三醇 (一)雌三醇(以下简称E_3)的来源:孕期E_3可由卵巢,胎盘及胎儿三方面产生,但以胎盘、胎儿为主。 1.胎盘合成雌激素的过程:见图一,由母体醋酸盐及胆固醇转化为孕烯醇酮、胎盘内仅有3β羟基类固醇脱氢酶和异构酶、而11β、16α、17α及21α羟化酶的含量极少,故不能使C-21类固醇转化为C-19类固醇,也不能转化为醣及盐类皮质醇。胎
In the recent ten years, more research has been done on the function of fetal placenta, which has played a certain role in the treatment of high-risk pregnancy and the reduction of perinatal death. Present situation is introduced. First, the estriol (A) of estriol (hereinafter referred to as E_3) Source: E3 during pregnancy can be generated from the ovary, placenta and fetus, but the placenta, the fetus. 1. placenta synthesis of estrogen process: see Figure 1, from the mother’s acetate and cholesterol into pregnenolone, the placenta only 3β hydroxysteroid dehydrogenase and isomerase, and 11β, 16α, 17α and 21α Hydroxylase content is very small, it can not make C-21 steroids into C-19 steroids, can not be converted to sugar and saline cortisol. fetal