头孢菌素类具有抗菌谱广、杀菌力强、低毒、品种多,临床应用广泛等特点。《中国药典》2005年版收载了15个品种,29个制剂。此类抗生素具有不稳定的β-内酰胺环,易受亲核、亲电试剂的攻击,与酸、碱及某些金属离子作用时,易发生水解和分子重排,导致其疗效降低和过敏反应增加。在临床用药时,药物相互作用及配伍合理性关系着临床用药的安全有效。近年来,注射用头孢菌素类抗生素与其他药物配 Cephalosporins with broad antibacterial spectrum, strong bactericidal, low toxicity, variety, wide range of clinical applications. The Chinese Pharmacopoeia 2005 edition contains 15 varieties and 29 preparations. Such antibiotics have unstable β-lactam ring, vulnerable to nucleophilic, electrophilic reagents attack, and acid, alkali and some metal ions, prone to hydrolysis and molecular rearrangement, resulting in reduced efficacy and allergies Response increased. In clinical medication, drug interactions and compatibility rationality of clinical drug use is safe and effective. In recent years, injection of cephalosporins antibiotics and other drugs with