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目的探讨不同短时收缩压变异性指标与老年人群颈动脉内膜中层厚度的关联。方法在参加开滦研究队列第三次健康体检的人群中,采取整群抽样的方法随机抽取年龄≥60岁的开滦集团离退休员工进行24h动态血压监测等检查。在随机抽取的3 064例研究对象中,符合入选标准的为2 464例,最终纳入统计分析的有1 518例。收缩压变异性(Systolic Blood Pressure Variability,SBPV)采用标准差(SD)、独立变异性(VIM)、极差(MMD)和平均真实变异性(ARV)四种指标。采用逐步线性回归方法,分析不同短时SBPV指标与颈动脉内膜中层厚度(CIMT)的关联。结果 (1)在1 518例研究对象中,年龄平均为(67.14±5.94)岁。其中,男性1 000例(65.9%),女性518例(34.1%)。(2)除短时VIM以外,平均收缩压(SBP)越高,短时SBPV均呈升高趋势(P值<0.05)。(3)在逐步线性回归分析中,不同24h、日间SBPV指标均与CIMT呈正线性相关,不同夜间SBPV指标均与CIMT无线性相关。结论不同24h、日间收缩压变异性指标与CIMT均存在一定程度的关联。
Objective To explore the relationship between different short-term systolic pressure variability indexes and carotid intima-media thickness in the elderly. Methods Participants in Kailu Research Cohort of the third health examination of the crowd, the method of cluster sampling randomly selected age ≥ 60-year-old Kailuan Group retired staff 24h ambulatory blood pressure monitoring and other tests. Of the 3,064 randomized participants, 2 464 met the inclusion criteria and 1 518 were finally included in the statistical analysis. Systolic Blood Pressure Variability (SBPV) using four indicators of standard deviation (SD), independent variability (VIM), very poor (MMD) and average real variability (ARV). The stepwise linear regression method was used to analyze the association of different short-term SBPV parameters with carotid artery intima-media thickness (CIMT). Results (1) Of the 1 518 study subjects, the average age was (67.14 ± 5.94) years. Of these, 1,000 were male (65.9%) and 518 were female (34.1%). (2) Except for short-term VIM, SBPV increased with the increase of SBP (P <0.05). (3) In the stepwise linear regression analysis, SBPV indexes of different 24h and day were positively correlated with CIMT, and SBPV indexes of different night were correlated with CIMT. Conclusions The differences of systolic blood pressure variability index and CIMT have different degrees of correlation at different 24h.