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目的:探讨黄芪当归合剂对肾病综合征患者肾功能、炎症机制及疗效的影响研究。方法:肾病综合征患者115例,依据随机数字表法随机分为观察组58例与对照组57例。对照组采用常规治疗,观察组在对照组基础上结合黄芪当归合剂治疗。两组疗程均为6个月。比较两组治疗前后肾功能指标、炎症因子水平变化,治疗疗效及药物不良反应发生情况。结果:两组Scr、BUN、24h尿蛋白定量、白蛋白治疗后明显降低(P<0.05);观察组Scr、BUN、24h尿蛋白定量、白蛋白治疗后低于对照组(P<0.05);两组IL-1、TNF-α、IL-6水平治疗后明显降低(P<0.05);观察组IL-1、TNF-α、IL-6水平治疗后低于对照组(P<0.05);观察组总有效率(93.10%)高于对照组(75.44%)(P<0.05);两组均未见严重不良反应。结论:黄芪当归合剂可明显改善患者肾功能,减轻患者微炎症状态,且疗效显著,安全可靠,值得研究。
Objective: To investigate the effect of Astragalus and Angelica mixture on renal function, inflammatory mechanism and therapeutic effect in patients with nephrotic syndrome. Methods: One hundred and fifteen patients with nephrotic syndrome were randomly divided into observation group (58 cases) and control group (57 cases) according to the random number table method. The control group with conventional treatment, the observation group in the control group combined with astragalus and Angelica mixture treatment. Two courses of treatment are 6 months. Before and after treatment, the renal function indexes, the changes of inflammatory cytokines, the curative effects and adverse drug reactions were compared between the two groups. Results: The proteinuria of Scr, BUN and 24 h were significantly decreased in both groups (P <0.05). The levels of Scr, BUN and urinary protein in the observation group were lower than those in the control group after treatment with albumin (P <0.05). The levels of IL-1, TNF-α and IL-6 in the two groups were significantly decreased after treatment (P <0.05). The levels of IL-1, TNF-α and IL-6 in the observation group were lower than those in the control group The total effective rate (93.10%) in the observation group was higher than that in the control group (75.44%) (P <0.05). No serious adverse reactions were observed in both groups. Conclusion: Radix Astragali and Angelica Mixture can significantly improve renal function and alleviate the micro-inflammatory state in patients with significant curative effect, which is safe and reliable and deserves to be studied.