在这篇简报中,我们将初步报告由于我们三个单位五年以来的通力协作最近获得有关全合成结晶牛胰岛素的研究成果。胰岛素的壹级结构是在十年前由Sanger等搞清楚的。近两年来有关胰岛素合成方面,已有不少报导。Katsoyannis等报导了羊胰岛秦A及B锭的合成,并按Dixon和Wardlaw的重组合方法,将所合成的A及B链进行组合,只能观察到微弱的胰岛素活力。Zahn、Meienhofer等从他们所合成的羊胰岛素的A及B链衍生物经钠氨处理脱去保护基因 In this briefing, we will initially report the results of our recent research on fully synthetic crystalline bovine insulin due to the concerted efforts of our three units over the past five years. One-level insulin structure was discovered by Sanger et al. Ten years ago. In the past two years, there have been many reports on insulin synthesis. Katsoyannis et al. Reported the synthesis of sheep A and B pro-Qin A and B, and according to the recombination method of Dixon and Wardlaw, the synthesized A and B chains were combined and only weak insulin activity was observed. Zahn, Meienhofer et al. Deprotect protected genes from sodium and ammonia derivatives of the A and B chain derivatives of sheep insulin that they synthesize