利用噬菌体表面显示技术，将蛋白质或短肽分子在噬菌体表面表达，可以对抗原表位及蛋白质的相互作用位点进行定位与模拟，并用于蛋白质的体外亲和力优化以及新基因的克隆，在小分子药物的设计和筛选中也具有重要的作用。环肽结构的设计以及筛选策略和方法的改进，逐步推动着噬菌体表面显示技术在免疫学、基因工程药物及基础生物医学研究等研究领域中的成功应用 The use of phage display technology, the protein or short peptide molecules expressed on the surface of the phage, antigen epitopes and protein interaction sites can be located and simulated, and used in protein affinity in vitro affinity and new gene cloning, in small molecules Drug design and screening also play an important role. The design of cyclic peptides and the improvement of screening strategies and methods have gradually promoted the successful application of bacteriophage surface display technologies in the fields of immunology, gene engineering and basic biomedical research