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目的 :对痔内注射安痔注射液及消痔灵后的组织病理学变化进行观察与比较。方法 :35例内痔混合痔患者中 ,注射安痔注射液治疗 2 5例、注射消痔灵治疗 10例。分别于治疗后的不同时间取活检标本 ,做病理组织学观察。结果 :注射安痔注射液后引起组织发生一种非炎症性的蛋白凝固样变性 ,血管收缩闭合 ,此变性可逆 ,容易“复活” ,经过 3d～ 7d ,可原位修复 ,无瘢痕形成 ,其间不发生明显的炎症、出血、坏死等改变。消痔灵注射后引起的是一种无菌性炎症 ,组织内出现明显水肿、出血、炎症反应 ,扩张静脉内血栓形成以及有瘢痕形成。结论 :消痔灵引起的水肿、出血及炎症反应等改变均明显重于安痔注射液 ,7d后的血栓机化、内皮细胞生长不如安痔注射液活跃 ,且在组织中引起瘢痕形成。
Objective: To observe and compare the histopathological changes of hemorrhoidin injection and Xiaozhiling injection. Methods: 35 cases of hemorrhoids patients with mixed hemorrhoids, injection of Ann hemorrhoids injection treatment of 25 cases, injection of Xiaozhiling 10 cases. At different times after treatment, biopsy specimens were taken for histopathological observation. Results: The injection of An hemorrhoids injection caused a non-inflammatory protein coagulation-like degeneration of the tissue, the vasoconstriction closed, the degeneration reversible, easy to “revive”, after 3d ~ 7d, can be repaired in situ, no scar formation during which No obvious inflammation, bleeding, necrosis and other changes. Xiaozhiling injection caused by aseptic inflammation, obvious edema within the organization, bleeding, inflammatory reaction, the expansion of venous thrombosis and the formation of scarring. Conclusion: The changes of edema, hemorrhage and inflammatory reaction induced by Xiaozhiling are obviously heavier than those of An hemorrhoids injection. After 7 days, the thrombosis and endothelial cell growth are not as active as Ann Hemorrhoids Injection and cause scarring in the tissue.