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据估计,目前世界上大约有二亿多人是乙型肝炎病毒的携带者;约有10%的急性乙型肝炎患者转为慢性;而慢性肝炎的发展可导致肝硬化,甚至肝癌。乙型肝炎既可通过输血、唾液及性接触水平传播,也可通过母——婴垂直传播。乙型肝炎正严重地威胁着人类的健康,控制和消灭乙型肝炎是医学科学面临的巨大挑战。目前,对乙型肝炎病毒(HBV)感染的临床表现、感染后患者血清中出现的各种病毒标志及其在病程中的消长规律,都有了比较清楚的了解。但这还只是根据乙型肝炎病毒活动所产生的结果所作的观察和研究,因而不能获得对HBV生物学特性的更深入的认识。目前,HBV还只能在人类和黑猩猩肝细胞内很好地复制。人们曾试图
It is estimated that about 200 million people in the world are carriers of the hepatitis B virus; about 10% of patients with acute hepatitis B turn chronic; and the development of chronic hepatitis can lead to cirrhosis and even liver cancer. Hepatitis B can be transmitted by blood transfusion, saliva and sexual contact levels, but also by mother-infant vertical transmission. Hepatitis B is a serious threat to human health, control and eradicate hepatitis B is a huge challenge facing the medical science. At present, the clinical manifestations of hepatitis B virus (HBV) infection, serum markers in patients after infection and the growth and decline in the law of the disease have a more clear understanding. However, this is only an observation and study based on the results of the Hepatitis B virus activity. Therefore, a deeper understanding of the biological characteristics of HBV can not be obtained. At present, HBV can only reproduce well in human and chimpanzee hepatocytes. People have tried