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1961年Herbert等首先注意到正常情况下脑脊液中叶酸盐活力的选择性浓度,1970年后据Spaas等观察,叶酸盐(Folate)进出似存在着一种有效的血脑屏障。1972年Hommes等发现,当热性损伤施用于大鼠时,其有效的血脑屏障系统可能受到损害而诱发抽搐发作。1983年本文作者报导,在热性惊厥时,血清和红细胞的叶酸盐水平增高,曾推测高热对有效血脑屏障有影响。脑脊液中叶酸盐和钴胺(Cobalamin)之间的关系了解甚少,热性惊厥小儿的钴胺情况亦未见报导。作者研究了热性惊厥小儿
In 1961, Herbert et al. First noticed the selective concentration of folate in cerebrospinal fluid under normal conditions. After 1970, according to Spaas et al., Folate appeared to have an effective blood-brain barrier. In 1972, Hommes et al found that when heat injury is applied to rats, the effective blood-brain barrier system may be damaged to induce convulsions. In 1983, the authors reported that in febrile seizures, the levels of folate in serum and erythrocytes were increased, and it was hypothesized that hyperthermia may have an effect on the effective blood-brain barrier. Little is known about the relationship between folic acid and Cobalamin in cerebrospinal fluid, and no reports of cobalamin in children with febrile seizures. The authors studied children with febrile seizures