非小细胞肺癌(NSCLC)转移依赖于肿瘤局部血管生成的理论已为广大学者认可。而事实上NSCLC似乎更易于经淋巴转移。由于缺乏明确的淋巴管生成因子和标记因子,对淋巴转移的研究进展缓慢,VEGF-C、D是迄今为止已发现的淋巴血管内皮细胞刺激因子〔1,2〕,通过其受体2(KDR)及受体3(Flt- The theory that non-small cell lung cancer (NSCLC) metastasis depends on tumor local angiogenesis has been recognized by the majority of scholars. In fact, NSCLC seems to be more prone to lymphatic metastasis. Due to the lack of clear lymphangiogenic factors and marker factors, the research on lymphatic metastasis is progressing slowly. VEGF-C and D are so far discovered lymphatic endothelial cell stimulating factors [1, 2] through their receptors 2 (KDR). ) and receptor 3 (Flt-