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目的观察无创呼吸机联合纳洛酮治疗老年慢性阻塞性肺疾病(COPD)并发呼吸衰竭的临床疗效。方法 84例老年COPD并发呼吸衰竭患者,随机分为观察组与对照组,每组42例。在常规治疗的基础上,对照组给予无创呼吸机治疗,观察组在对照组基础上联合应用纳洛酮进行治疗;比较两组疗效、住院时间及二次插管率。结果观察组总有效率为92.86%,显著高于对照组76.19,差异具有统计学意义(P<0.05)。观察组住院时间和二次插管率均显著低于对照组,差异具有统计学意义(P<0.05或P<0.01)。结论无创呼吸机联合纳洛酮治疗老年COPD并发呼吸衰竭疗效显著,值得临床推广。
Objective To observe the clinical efficacy of noninvasive ventilator combined with naloxone in the treatment of senile chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods Eighty-four elderly COPD patients with respiratory failure were randomly divided into observation group and control group with 42 cases in each group. On the basis of routine treatment, the control group was given noninvasive ventilator treatment. The observation group was treated with naloxone on the basis of the control group. The curative effect, length of stay and the rate of secondary intubation were compared between the two groups. Results The total effective rate in the observation group was 92.86%, which was significantly higher than that in the control group (76.19), the difference was statistically significant (P <0.05). The hospitalization time and secondary intubation rate in the observation group were significantly lower than those in the control group, with statistical significance (P <0.05 or P <0.01). Conclusion Noninvasive ventilator combined with naloxone in elderly patients with COPD complicated by respiratory failure has a significant effect and is worthy of clinical promotion.