论文部分内容阅读
为探讨肿瘤转移抑制基因ｎｍ２３与涎腺腺样囊性癌（ａｄｅｎｏｉｄｃｙｓｔｉｃｃａｒｃｉｎｏｍａ，ＡＣＣ）的关系，应用ＬＳＡＢ免疫组化染色方法，研究ｎｍ２３表达产物二磷酸核苷激酶（ｎｕｃｌｅｏｓｉｄｅｄｉｐｈｏｓｐｈａｔｅｋｉｎａｓｅ，ＮＤＰＫ）在ＡＣＣ中的表达。结果：ＮＤＰＫ／ｎｍ２３在ＡＣＣ中有较高表达，阳性率为６４．０％（１６／２５）；其中，有肺转移者阳性率为１２．５％（１／８），无转移者阳性率为８８．２（１５／１７），差异有极显著性（Ｐ＜０．０１）；ＮＤＰＫ表达与临床分期有关，分期越高，阳性率越低，差异有显著性（Ｐ＜０．０５），与病理分型差异无显著性（Ｐ＞０．０５）。结论：ｎｍ基因在人ＡＣＣ肺转移过程中起到抑制转移的作用，可作为临床预测ＡＣＣ患者转移和预后的指标。
To investigate the relationship between the tumor suppressor gene nm23 and adenoid cystic carcinoma (ACC), LSAB immunohistochemical staining was used to study the expression of nm23 expression product (NDPK) in ACC . Results: The positive expression rate of NDPK / nm23 in ACC was 64.0% (16/25). Among them, the positive rate of lung metastasis was 12.5% (1/8), the positive rate of non-metastasis (P <0.01). The expression of NDPK was correlated with clinical stage. The higher the stage was, the lower the positive rate was, the difference was significant (P <0.05) , No significant difference with the pathological type (P> 0.05). CONCLUSIONS: The nm gene plays a role of inhibiting metastasis in human ACC lung metastasis and can be used as an index to predict the metastasis and prognosis of ACC patients.