目的观察比较地塞米松甲状腺内注射和口服泼尼松治疗亚急性甲状腺炎的疗效。方法A组甲状腺内注射地塞米松,并口服安慰剂;B组口服泼尼松,同时行甲状腺内注射生理盐水,并设定观察项目及疗效标准。结果A组体温开始下降的时间、疼痛开始缓解时间和甲状腺开始缩小时间较B组短,两组比较差异有统计学意义。结论口服泼尼松治疗亚急性甲状腺炎疗效不明显时,可考虑行地塞米松甲状腺内注射。 Objective To compare the efficacy of dexamethasone intrathymic injection and oral prednisone in the treatment of subacute thyroiditis. Methods Group A received intrathyroideal injection of dexamethasone and oral placebo. Group B received prednisone orally and injected normal saline into the thyroid gland. The observation items and the standard of efficacy were set. Results The time when the body temperature began to drop in Group A, the pain relief time and thyroid gland contraction time were shorter than those in Group B, the difference was statistically significant between the two groups. Conclusion oral prednisone treatment of subacute thyroiditis curative effect is not obvious, may consider dexamethasone thyroid injection.