肝豆状核变性(Wilson’s)病,目前大多用青霉胺治疗,虽然大部分患者可获改善,但约有30%的病人于用药2周内即出现毒性反应,如皮疹、发热、嗜酸性细胞增多、白细胞及血小板减少等。甚至可引起致命性的粒细胞缺乏症。约10%的病人或早或晚对青霉胺可能发生不耐受。而且用青霉胺治疗其临床症 Wilson’s disease is currently mostly treated with penicillamine. Although most patients are improved, about 30% of patients develop toxic reactions such as rash, fever and eosinophilia within 2 weeks of treatment Increased cells, white blood cells and thrombocytopenia. Can even cause fatal agranulocytosis. Approximately 10% of patients may be intolerant of penicillamine sooner or later. And penicillamine treatment of its clinical symptoms