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４４例单纯性肾病患儿．随机分为强的松治疗单剂组和分剂组，单剂组共１９例，其中男１４例，女５例，年龄（Ｘ±ｓ）为７．２１±３．５２；分剂组共２５例，其中男１８例，女７例，年龄为７．５４±４．２４．强的松按每２ｍｇ／（ｋｇ·ｄ）给予，单剂组为早晨一次顿服，分剂组则分３～４次服。从第５周开始，按２ｍｇ／（ｋｇ·ｄ），隔日早晨一次顿服。两组减量方法相同。临床研究表明，两组诱导缓解时间较为接近，诱导缓解时间单剂组为１０．８１±３．６１ｄ，分剂组为１１±３．８９ｄ（Ｐ＞０．０５）．但每日单剂组的柯兴氏征、高血压及食欲亢进等药物副作用明显低于每日分剂组。说明单剂组疗效相同，但药物副作用少，值得临床推广使用。
44 cases of simple nephrotic children. Randomly divided into prednisone treatment of single dose group and divided dose group, a single dose group of 19 cases, including 14 males and 5 females, age (X ± s) was 7.21 ± 3.52; 25 cases, including 18 males and 7 females, aged 7.54 ± 4.24. Prednisone at 2mg / (kg · d) given, a single dose group for the morning meal, sub-dose group is divided into 3 to 4 times service. From the fifth week, according to 2mg / (kg · d), the next morning Dayton clothing. The same two methods of reduction. Clinical studies show that the two groups of induction of remission time is closer to the induction of remission time of single-agent group was 10.81 ± 3.61d, divided into groups of 11 ± 3.89d (P> 0.05). However, the single dose group of Cushing’s syndrome, hypertension and hyperalgesia and other drugs side effects were significantly lower than the daily dose group. Single-dose group that the same effect, but less side effects of drugs, it is worth to promote clinical use.