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目的研究羟基喜树碱(HCPT)联合吡柔比星(THP)治疗涎腺腺样囊性癌(ACC)的合理用药顺序。方法60只裸鼠建立ACC肺转移动物模型后,将动物随机分为6组,分别按6种用药顺序组合治疗。6周后处死各组动物并取完整肺部标本,经图像分析测量肿瘤面积。结果化疗各组肿瘤面积明显小于空白对照组(P<0·01);HCPT和THP同时给药组和两单药组差异无统计学意义(P>0·05),但两药顺序给药或间隔48h给药组与2个单一给药组及两药同时给药组比较,差异有统计学意义(P<0·05)。结论HCPT联合THP在治疗ACC肺转移时具有协同效应,但应避免同时给药。
Objective To study the reasonable medication sequence of salicyclinic adenoid cystic carcinoma (ACC) treated with HCPT combined with pirarubicin (THP). Methods 60 nude mice were established animal model of lung metastasis of ACC, the animals were randomly divided into 6 groups, respectively, according to the six kinds of medication combination treatment. After 6 weeks, all animals were sacrificed and the whole lung specimens were taken. The tumor area was measured by image analysis. Results The tumor area in each group was significantly smaller than that in the blank control group (P <0.01). There was no significant difference between the HCPT and THP groups and the two single drug groups (P> 0.05) (P <0.05), or 48h interval group and 2 single dose group and two drug simultaneous administration group. Conclusions HCPT combined with THP has a synergistic effect in the treatment of ACC lung metastasis, but should be avoided at the same time.