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目的：探讨急性重复高原缺氧对机体氧自由基代谢的影响。方法：对担负军事运输的某汽车部队随机挑选16名驾驶员，在开运前10天（海拔1400m）、完成4次高原（海拔1400-5400m）运输任务中途（海拔3700m）及运输任务结束（完成8次高原运输任务）后1个月（海拔1400m），分别进行3次血中抗氧化酶、抗氧化物和脂质过氧化物的检测。结果：运输前轻运输中途血红蛋白（Hb）、脂质过氧化物（LPO）、丙二醛（MDA）低，相差非常显著（P＜0．01）；红细胞超氧化物歧化酶（RBC—SOD）和VitE高，相差显著（P＜0．05）；运输前较运输后RBC－SOD和VitE高，LPO和MDA低，均相差非常显著（P＜0．01）。运输中途较运输结束Hb和RBC－SOD增高，相差非常显著和相差显著（P＜0．01和P＜0．05）。结论：低氧应激状态下和重复应激作用停止后的一定时间内，体内脂类过氧化活动显著增强，且持续时间较长。
Objective: To investigate the effects of acute hypoxia on oxygen free radical metabolism in the body. Methods: A total of 16 drivers were selected randomly from a car unit responsible for military transport. During the 10 days before the opening (1400m above sea level), four medium-altitude (1400-5400m above sea level) transport tasks (3700m above sea level) and transport operations were completed 1 month after the completion of 8 plateau transport missions) (1400m above sea level), 3 times of blood antioxidant enzymes, antioxidants and lipid peroxidation were detected. Results: Hb, LPO and MDA were lower in the light transport before transport (P <0.01). The levels of erythrocyte superoxide dismutase (RBC-SOD) ) And VitE (P <0.05). Before transportation, the RBC-SOD and VitE levels were higher, LPO and MDA were lower (P <0.01). The difference between Hb and RBC-SOD during transport was higher than that at the end of transport, with significant difference and significant difference (P <0.01 and P <0.05). CONCLUSIONS: Lipid peroxidation activity is significantly increased in hypoxia stress and within a certain period of time after repeated stress is stopped, and its duration is longer.