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以成年SD大鼠去卵巢建立骨质疏松模型 ,用骨形态计量学方法 ,研究了 8周的大强度和中等强度 (分别为2 0m/min和 30m/min ,1h/day,5d/week)跑台运动对大鼠胫骨近心干骺端松质骨骨量的影响。结果 :去卵巢安静组大鼠骨量减少 (%Tb .Ar:- 75 % ,p <0 .0 1;Tb.N :- 74% ,p <0 .0 1) ,骨形成增加 (BFR/BS :+ 115 % ,BFR/BV :+ 12 3% ,P <0 .0 1)、骨吸收增加 (Oc .No+ 2 2 9% ,p <0 .0 1) ,为高转换型的骨代谢。中等强度运动的去卵巢大鼠比去卵巢安静大鼠骨形成减少 (%L .Pm :- 42 % ,BFR/BS :- 36 % ,P <0 .0 5 ) ,骨吸收减少 (Oc .No:- 42 % ,p <0 .0 5 ) ,高转换受到抑制 ,骨量增加 (%Tb .Ar:+ 5 3% ,p <0 .0 5 ;Tb .N :+ 6 9% ,p <0 .0 1) ,但仍比正常组大鼠骨量降低 (%Tb .Ar:- 6 1% ,p <0 .0 1)。去卵巢后大强度运动与去卵巢安静组大鼠各项指标相比无显著性差异 (p >0 .0 5 ) ,与中等强度运动比骨形成增加(BFR/BS :+ 12 1% ,P <0 .0 1) ,骨吸收增加 (Oc .No:+ 10 3% ,p <0 .0 5 ) ,骨量减少 (%Tb .Ar:- 37% ,p <0 .0 5 ) ,仍为高转换型骨代谢。结论 :大鼠去卵巢后中等强度运动通过抑制高骨转换可减少骨丢失 ,减轻骨质疏松的程度 ,大强度运动对减轻骨质疏松的程度无作用。
Osteoporosis models were established in ovariectomized adult SD rats. Bone morphometry was used to study the effects of high intensity and moderate intensity at 8 weeks (20m / min and 30m / min, 1h / day, 5d / week) Effect of Treadmill Exercise on Mass of Cancellous Bone in Near Tibia Tissue of Rats. Results: In the ovariectomized rats, the bone mass decreased (% Tb. Ar: -75%, p <0.01; Tb.N: -74%, p < BS: + 115%, BFR / BV: + 123%, P <0.01) and increased bone resorption (Oc. No + 229; p <0.01) . Moderate-intensity exercise in ovariectomized rats reduced bone formation (% L. Pm: -42%, BFR / BS: -36%, P < : - 42%, p <0.05), high conversion was inhibited, bone mass increased (% Tb.Ar: +5 3%, p <0 05; Tb .N: + 69%, p < 0. 01), but still lower bone mass than the normal rats (% Tb. Ar: -6 1%, p <0.01). After ovariectomized exercise, there was no significant difference between each group (p> 0.05) and the moderate intensity exercise (BFR / BS: + 12.1%, P <0. 01), increased bone resorption (Oc. No: +10 3%, p <0.05), osteopenia For high conversion bone metabolism. Conclusion: After ovariectomized, moderate exercise can reduce bone loss and reduce the degree of osteoporosis by inhibiting high bone turnover. High intensity exercise has no effect on reducing osteoporosis.