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这两种针剂的性质和制造方法很相似。它们的特性是:(1)PH 值是一切针剂中最高的(9.5-10.5),因此对玻璃安瓿有特殊的要求;(2)全部制造过程中必须避免二氧化碳气。现在各制造单位所遭遇的困难主要有下列四方面:(1)脱片(剥皮)——刚灭菌好的或放置一个时期后,安瓿中有玻璃脱片出现。解决的方法是采用耐碱安瓿。(2)结晶——刚灭菌后或放置一个时期后;安瓿中出现大小不同的结晶,这是因为吸收二氧化碳气的关系而析出磺胺嘧啶或磺胺噻唑。解决的方法是在全部制造过程中尽力避免溶液吸收二氧化碳气。(3)
The nature of the two injections is very similar to the method of manufacture. Their characteristics are: (1) PH is the highest of all injections (9.5-10.5) and therefore has special requirements for glass ampoules; and (2) carbon dioxide gas must be avoided throughout the manufacturing process. At present, the difficulties encountered by various manufacturing units are mainly in the following four aspects: (1) Debinding (peeling) -After the glass has been sterilized or placed for a period of time, glass ampoules are peeled off. The solution is to use alkali-proof ampoule. (2) Crystallization - Just after sterilization or after a period of storage; crystals of different sizes appear in the ampoules due to the absorption of carbon dioxide gas and the precipitation of sulfadiazine or sulfathiazole. The solution is to try to avoid solution absorption of carbon dioxide gas throughout the manufacturing process. (3)