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目的:探讨血浆同型半胱氨酸(HCY)与原发性高血压(EH)的关系以及与危险因素的相关性。方法:采取整群随机抽样的方法抽取调查样本,选择徐州市大屯社区369例中年居民为调查对象,运用病例对照研究方法,通过酶联免疫吸附法测定血浆HCY水平,并作统计学处理。结果:①EH组血浆HCY水平高于对照组(P<0.05),EH组高HCY血症(血浆HCY浓度>15μmol)为36.2%,对照组为21.6%,差异有统计学意义(P <0.05)。②血浆HCY水平与三酰甘油、收缩压、舒张压呈正相关(r=0.108-0.139,P<0.05),与载脂蛋白A 呈负相关(r=-0.189.均P<0.05),但其相关性较弱,且血浆HCY水平与其他危险因素之间未发现明显相关性。结论:血浆HCY不仅是EH发生的一个危险因素,可能还是一个独立的危险因素。检测血浆HCY水平对EH的预防、诊疗具有重要临床价值。
Objective: To investigate the relationship between plasma homocysteine (HCY) and essential hypertension (EH) and risk factors. Methods: A total of 369 middle-aged residents in Datun community in Xuzhou were enrolled in this study. Samples were collected by random sampling method. Case-control study was used to determine plasma HCY levels by enzyme-linked immunosorbent assay . Results: ① The plasma HCY levels in the EH group were significantly higher than those in the control group (P <0.05). The HCG hyperlipidemia (plasma HCY concentration> 15 μmol) in EH group was 36.2% and 21.6% in the control group (P <0.05) . ② Plasma HCY level was positively correlated with triglyceride, systolic pressure and diastolic pressure (r = 0.108-0.139, P <0.05), but negatively correlated with apolipoprotein A (r = -0.189, all P <0.05) The correlation was weak, and no significant correlation was found between plasma HCY level and other risk factors. Conclusion: Plasma HCY is not only a risk factor of EH, but also an independent risk factor. Detection of plasma HCY levels of EH prevention, diagnosis and treatment has important clinical value.