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在胶原存在条件下低密度脂蛋白（ＬＤＬ）的氧化反应性的改变一直未见报道，通过在体外分离大鼠Ｉ型胶原并制成胶原凝胶，发现铜离子（Ｃｕ２＋）介导的ＬＤＬ氧化反应的潜伏期明显延长，所生成的硫代巴比妥酸反应物（ＴＢＡＲＳ）最大值远低于对照组，胶原组氧化ＬＤＬ（ｏｘ－ＬＤＬ）的相对电泳迁移率（ＲＥＭ）也较对照组为低；在偶氮类化合物２，２′－盐酸脒基丙烷（ＡＡＰＨ）诱导的ＬＤＬ氧化过程中，胶原组与对照组的ＬＤＬ氧化反应潜伏期相似，ＴＢＡＲＳ生成值差别不明显。这些结果提示：Ｉ型胶原的存在可降低ＬＤＬ对Ｃｕ２＋介导的氧化反应敏感性，其机制可能与捕获自由基无关。
Changes in the oxidative reactivity of low density lipoproteins (LDLs) in the presence of collagen have not been reported and copper ion (Cu2 +) -mediated LDL oxidation was found by isolating rat type I collagen in vitro and making a collagen gel The latency of the reaction was significantly prolonged. The maximum value of TBARS was much lower than that of the control group. The relative electrophoretic mobility (REM) of oxidized LDL (ox-LDL) The LDL oxidation reaction between collagen group and control group was similar in the azo compound 2,2’-amidino-propane (AAPH) -induced LDL oxidation. The difference of TBARS generation value was not obvious. These results suggest that the presence of type I collagen reduces the susceptibility of LDL to Cu2 + -mediated oxidative reactions and may not be related to the capture of free radicals.