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实验和临床研究中,决定心肌氧消耗(MVO_2)的主要机械因素例如心率、心肌内张力和收缩状态等的变化,深深影响心肌缺血性损害的程度。心肌的底物供应似乎也影响氧需要,健康心肌过度利用游离脂肪酸(FFA)能增加氧消耗,而高浓度血浆 FFA
In experimental and clinical studies, changes in major mechanical factors that determine myocardial oxygen consumption (MVO2), such as heart rate, intramyocardial tension and contractility, have a profound impact on the extent of myocardial ischemic injury. Myocardial substrate supply also appears to affect oxygen demand, excessive use of free fatty acids (FFA) by healthy myocardium increases oxygen consumption, and high concentrations of plasma FFA