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目的评价异基因外周造血干细胞移植后急性移植物抗宿主病发生情况。方法42例恶性血液病患者,采用马利兰、环磷酰胺预处理,用环孢素A+甲氨喋呤预防移植物抗宿主病,输入有核细胞中位数9.61(4.00~17.18)×108.kg-1,进行同胞相合外周造血干细胞移植。结果17例发生急性移植物抗宿主病,16例患者出现皮疹,以斑丘疹为主,4例有胃肠道症状,其中6例有肝脏受累。结论急性移植物抗宿主病的发生及其程度直接影响到移植病人的预后,而皮疹则是移植物抗宿主病的一个重要标志。
Objective To evaluate the incidence of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. Methods Forty-two patients with hematologic malignancies were treated with maryland and cyclophosphamide pretreatment. Cyclosporine A + methotrexate was used to prevent graft-versus-host disease. The median of nucleated cells was 9.61 (4.00-17.18) × 108.kg -1 for sibling peripheral hematopoietic stem cell transplantation. Results Acute graft-versus-host disease occurred in 17 patients. A rash occurred in 16 patients with maculopapular rash. Four patients had gastrointestinal symptoms, of which 6 patients had liver involvement. Conclusion The incidence and extent of acute graft-versus-host disease directly affect the prognosis of transplant patients, while the rash is an important marker of graft-versus-host disease.