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目的 探讨柳氮磺吡啶(SSZ)、雷公藤多甙(T2)、甲氨蝶呤(MTX)等缓作用抗风湿药在强直性脊柱炎(AS)治疗中的地位。方法 追踪230例AS0.5～8a治疗情况,观察其临床、实验室及影像学等方面的变化。结果 单独和联合用药均可使临床和实验室指标得到改善,部分病人骶髂关节炎得到控制甚至改善;髋关节受累者骶髂关节炎较重。结论 SSZ、T2、MTX均对AS有效,SSZ对中轴型AS也有效,联合用药可提高疗效;AS治疗应在3a以上;髋受累是病情严重性及预后不良的指标之一。
Objective To investigate the effects of anti-rheumatoid drugs such as sulfasalazine (SSZ), triptolide (T2) and methotrexate (MTX) in the treatment of ankylosing spondylitis (AS). Methods 230 AS0.5 ~ 8a patients were followed up and their clinical, laboratory and imaging changes were observed. Results Both alone and in combination could improve the clinical and laboratory parameters, and some patients had control or even improvement of sacroiliitis. Patients with hip joint had severe sacroiliac arthritis. Conclusions Both SSZ, T2 and MTX are effective on AS, while SSZ is also effective on axial AS. Combination therapy can improve the therapeutic effect. AS treatment should be above 3a. Hip involvement is one of the indicators of the severity and prognosis.