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目的:考察注射用氯诺昔康与盐酸氯胺酮注射液在0.9%氯化钠注射液中的稳定性。方法:采用高效液相色谱法,测定注射用氯诺昔康与盐酸氯胺酮注射液配伍后在室温条件下72h内的含量变化,并观察和检测配伍液的外观及pH变化。结果:配伍液中盐酸氯胺酮含量与pH无明显变化,氯诺昔康的含量逐渐降低,配伍液24h后出现少量沉淀。结论:室温条件下,注射用氯诺昔康与盐酸氯胺酮注射液在0.9%氯化钠注射液中不稳定,临床不宜配伍应用。
Objective: To investigate the stability of injection of lornoxicam and ketamine hydrochloride injection in 0.9% sodium chloride injection. Methods: The contents of lornoxicam injection and ketamine hydrochloride injection were determined by high performance liquid chromatography (HPLC) at room temperature for 72 hours. The appearance and pH of the compatibility solution were observed and detected. Results: The content of ketamine hydrochloride did not change obviously with the pH value, and the content of lornoxicam gradually decreased. A small amount of precipitate appeared after 24h compatibility. Conclusion: In room temperature, injection of lornoxicam and ketamine hydrochloride injection in 0.9% sodium chloride injection is unstable and should not be used clinically.