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甲硝唑(Metronidazole)除了抗滴虫和抗阿米巴原虫外,临床上广泛用于抗厌氧菌感染。常见的不良反应有恶心、腹痛、呕吐、金属味、荨麻疹及可逆的嗜中性粒细胞减少等。随着在临床上的广泛应用,有关的不良反应报道日益增多。现综述如下。 1 过敏反应 1.1 过敏性休克 兰新辉等报道1女性患者因慢性支气管炎合并肺内感染,给予0.2％甲硝唑250ml静脉滴注,未用其它药物治疗。20min后,患者出现手、足、面部奇痒,心悸、胸闷、呼吸困难,咽喉填塞感,声音嘶哑、头晕,BP10.6/0kPa,心率130次
Metronidazole is widely used in clinical practice against anaerobic infections in addition to trichomonad and anti-amoebae. Common adverse reactions are nausea, abdominal pain, vomiting, metallic taste, urticaria and reversible neutropenia. With the wide application in clinic, the related adverse reactions are reported increasing day by day. Are summarized below. Anaphylaxis 1.1 Allergic Shockland Xinhui et al reported that 1 female patients with chronic bronchitis and pulmonary infection, giving metronidazole 0.2ml intravenous infusion of 250ml, without the use of other drugs. After 20 minutes, the patient showed hand, foot, facial itching, palpitations, chest tightness, difficulty breathing, throat filling, hoarseness, dizziness, BP10.6 / 0kPa, heart rate 130