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作者鉴于常用口服降血糖药磺酰脲类(Ⅰ)的结构改变后,能找到剂量小而疗效较高的药物,因而对磺胺嘧啶类(Ⅱ)的结构进行改造,并探讨化学结构与生理作用间的关系,所合成的各类化合物的通式为(Ⅲ):
In view of the structural changes of the commonly used oral hypoglycemic agents sulfonylureas (I), we can find the drugs with small dose and high efficacy, so the structure of sulfadiazine (Ⅱ) is modified and the chemical structure and physiological functions The relationship between the various compounds synthesized by the general formula (III):