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目的：了解妊高征产妇叶酸代谢特点及其与新生儿体重的关系。方法：采用放射免疫分析法测定产妇静脉血清、脐血及乳汁中叶酸浓度并进行比较分析。结果：1．妊高征产妇血清及脐血叶酸浓度显著低于正常产妇，而初乳中叶酸浓度则与正常产妇无差异。2．妊高征产妇新生儿体重显著低于正常产妇新生儿。结论：妊高征产妇静脉血清及脐血中叶酸浓度明显降低．可能是妊高征产妇新生儿体重低于正常产妇新生儿体重的一个重要原因，提示对妊高征孕产妇，除积极治疗外，补充叶酸也非常必要。
Objective: To understand the characteristics of folic acid metabolism in pregnant women with PIH and its relationship with the weight of neonates. Methods: Radioimmunoassay was used to determine the concentration of folic acid in maternal venous serum, umbilical cord blood and milk, and comparative analysis was conducted. Results: 1. Pregnancy-induced hypertension in maternal serum and cord blood folic acid concentrations were significantly lower than normal maternal serum concentrations of colorectal follicles and normal maternal no difference. 2. Pregnancy-induced maternal newborn weight was significantly lower than normal maternal newborn. Conclusion: The concentration of folic acid in pregnant women with PIH is significantly lower than that in pregnant women. Preeclampsia may be newborns weighing less than normal maternal newborn weight is an important reason, suggesting that pregnant women with PIH, in addition to active treatment, the addition of folic acid is also very necessary.