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目的探讨缩宫素配伍安定、654-2用于足月胎膜早破患者引产的安全性与有效性。方法 86例未临产足月胎膜早破孕妇随机分为A、B两组,分别单用缩宫素及缩宫素配伍使用安定、654-2引产,观察两组临床结果。结果缩宫素配伍使用安定、654-2组较单用缩宫素组,引产用药至临产时间、第一产程及总产程时间均明显较组缩短,两组比较差异有统计学意义(P<0.05),剖宫产率明显降低(P<0.01),而两组胎儿窘迫、产后出血量及产褥病率差异无统计学意义。结论对足月妊娠胎膜早破患者,应用缩宫素配伍安定、654-2引产是一种安全、有效的引产方法。
Objective To investigate the safety and efficacy of oxytocin combined with diazepam and 654-2 for induction of labor in term preterm premature rupture of membranes. Methods Totally 86 pregnant women without full-term preterm rupture of membranes were randomly divided into A and B groups. The patients were treated with oxytocin and oxytocin alone, and stable and 654-2 induced abortion. The clinical outcomes of the two groups were observed. Results The combination of oxytocin and diazepam was more stable in group 654-2 than in group C, and the time to induction of labor, the time of first delivery and the duration of labor were significantly shorter than those in group 654-2 (P < 0.05). The rate of cesarean section was significantly lower (P <0.01). There was no significant difference between the two groups in fetal distress, postpartum hemorrhage and puerperal morbidity. Conclusion For full-term pregnancy in patients with premature rupture of membranes, the application of oxytocin and stability, 654-2 induction of labor is a safe and effective method of induction of labor.