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钙调素 (ｃａｌｍｏｄｕｌｉｎ ,ＣａＭ )是细胞内最重要的钙结合蛋白之一 ,对调节细胞分裂、增殖起重要作用。近年来发现钙调素拮抗剂有一定的抗癌活性 ,其突出特点是 :(1)它可以抑制肿瘤细胞的增殖 ,可使癌细胞生长阻断在Ｇ1 Ｓ期转换上[1] ;(2 )它可以使肿瘤细胞向正常细胞?
Calmodulin (CaM), one of the most important calcium-binding proteins in cells, plays an important role in regulating cell division and proliferation. In recent years, it has been found that calmodulin antagonists have certain antitumor activity. Its salient features are: (1) it can inhibit the proliferation of tumor cells, and can block the growth of cancer cells in G1 phase S conversion [1]; (2 ) Can it make tumor cells to normal cells?