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目的:研究中医不同治法的代表药物沙参、水蛭、黄芩、人参抗实验性小鼠肺纤维化的作用。方法:将60只小鼠随机分为正常组、模型组、沙参组、水蛭组、黄芩组、人参组。用暴露式气管内注入法造模后,于7天和28天处死动物,测定肺系数、肺组织病理及肺组织羟脯氨酸(HYP)。结果:各治疗组与模型组比较,28在肺系数明显降低(P<0.05);病理显示各治疗组较模型组肺泡炎及肺纤维化轻;且以水蛭组、沙参组为优;HYP含量水蛭组、沙参组明显低于模型组(P<0.05),其它组与模型组比较无显著性差异(P>0.05)。结论:不同治则代表药物均可在不同程度上改善博莱霉素所致的小鼠肺纤维化,其中以滋阴、活血的代表药物沙参、水蛭为优。
OBJECTIVE: To study the effects of different drugs on the pulmonary fibrosis of experimental mice, including Radix Astragali, Radix Astragali, Radix Astragali, and Radix Ginseng. Methods: 60 mice were randomly divided into normal group, model group, Adenophora group, Shuizhan group, Huangqi group, and ginseng group. After modeling with the exposed endotracheal injection method, the animals were sacrificed at 7 days and 28 days, and lung coefficient, lung histopathology, and lung tissue hydroxyproline (HYP) were measured. RESULTS: Compared with the model group, the lung coefficient of each treatment group was significantly lower than that of the model group (P<0.05). The pathology showed that each treatment group was milder than alveolitis and pulmonary fibrosis in the model group; The contents of Minamata and Adenophora were significantly lower than those of the model group (P<0.05). There was no significant difference between the other groups and the model group (P>0.05). Conclusion: Different drugs represent different drugs can improve the degree of bleomycin-induced pulmonary fibrosis in mice, with Yin and blood on behalf of the drug Adenophora, leeches are excellent.