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目的：探讨银杏叶提取物（ＥＧｂ）对大鼠应激性胃溃疡发生的保护作用及其机制。方法：雄性Ｗｉｓｔａｒ大鼠，随机分成对照组和ＥＧｂ 处理组；以冷拘束法建立应激性溃疡模型，通过胃窦部埋置电极记录应激状态胃平滑肌自发电活动的变化，并测定血浆和胃粘膜组织丙二醛（ＭＤＡ）含量和胃粘膜的病理改变。结果：ＥＧｂ１０～４０ ｍ ｇ／ｋｇ预处理可显著压抑应激所致的胃肌电活动紊乱及血浆和胃粘膜组织ＭＤＡ 水平的异常升高（Ｐ＜ ０．０５ 或Ｐ＜ ０．０１），使胃粘膜溃疡指数明显降低（Ｐ均＜ ０．０５），并具有剂量依从性。结论：ＥＧｂ 对冷束缚应激引起的大鼠胃粘膜损伤有明显的保护作用，其机制可能是通过改善胃平滑肌动力障碍和清除自由基来实现的。
Objective: To investigate the protective effect of Ginkgo biloba extract (EGb) on stress gastric ulcer in rats and its mechanism. METHODS: Male Wistar rats were randomly divided into control group and EGb treatment group. The stress ulcer model was established by cold binding method. The changes of self-generating activity of gastric smooth muscle in stress state were recorded by sinus embedded electrodes, and plasma and Malondialdehyde (MDA) content in gastric mucosa and pathological changes in gastric mucosa. RESULTS: Pretreatment with EGb 10-40 μg/kg significantly suppressed gastric myoelectric activity disorder and abnormally elevated plasma and gastric mucosal MDA levels (P<0.05 or P<0.01). The ulcer index of gastric mucosa was significantly reduced (all P < 0.05), and it was dose-dependent. Conclusion: EGb has obvious protective effect on gastric mucosal injury induced by cold-restraint stress in rats. The mechanism may be achieved by improving gastric smooth muscle dysmotility and eliminating free radicals.