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目的 观察胃癌间质组织中血管内皮细胞(EC)早期病变,探讨血管EC增生性改变在肿瘤发生、发展过程中作用。 方法 利用手术切除胃癌组织和化学诱发大鼠胃癌,观察血管结构特征并用抗人和抗鼠免疫组化进行标记。 结果 肿瘤间带血管EC明显增生,约占血管总数的60％,这些增生的血管EC,有的形成腺样结构,有的异形和癌变。 结论 胃癌间质血管KC的病理性改变,是肿瘤发生、发展的重要因素,抗人Ⅷ因子和抗鼠VEGF阳性也说明血管EC增生是肿瘤相关性病变。
Objective To observe the early lesions of vascular endothelial cells (EC) in gastric cancer interstitial tissues, and to explore the role of vascular EC proliferative changes in tumorigenesis and development. Methods Surgical resection of gastric cancer tissues and chemically induced rat gastric cancer were performed to observe the structural features of the blood vessels and to label them with anti-human and anti-rat immunohistochemistry. RESULTS: Tumors showed a marked hyperplasia of vascular ECs, accounting for about 60% of the total number of blood vessels. These hyperplastic ECs, some of which formed adenoid structures, some were abnormal and cancerous. Conclusion The pathological changes of gastric interstitial vascular KC are important factors in the occurrence and development of tumors. Anti-human factor VIII and anti-mouse VEGF positive also indicate that vascular EC hyperplasia is a tumor-related lesion.