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采用随机双盲法,用普拉睾酮钠治疗宫颈不成熟的120例孕妇,其中用国产的普拉睾酮钠91例为研究组,29例使用日本的麦力斯作为对照组。两组孕妇用药前年龄、孕周、宫颈评分、产科合并症的基础情况无统计学差异。研究结果表明实验组宫颈评分显效者为39.6%,有效者为58.2%,仅2.2%无效,对照组依次分别为48.2%,51.7%及0%。总有效率实验组为97.8%、对照组为100%。P>0.05。两组产程、分娩方式、产后出血量、新生儿出生状况、孕妇的副反应、血压、脉博、呼吸、24h尿量、肝肾功能、电解质等方面均无显著差异。上述结果证实国产的普拉睾酮钠是一种有效的促进宫颈成熟的药物。
A randomized, double-blind method was used to treat 120 cases of pregnant women with cervical premature uterine bleeding. Among them, 91 cases were made of domestic testosterone sodium and 29 cases were used as control group. The two groups of pregnant women before treatment, gestational age, cervical score, obstetric complications based on no significant difference. The results showed that 39.6% of the patients in the experimental group were markedly effective, 58.2% of whom were effective, and only 2.2% were ineffective. The control group was 48.2%, 51.7% and 0% respectively. The total effective rate was 97.8% in the experimental group and 100% in the control group. P> 0.05. There were no significant differences in labor, delivery mode, postpartum hemorrhage, neonatal birth, pregnant women with side effects, blood pressure, pulse, respiration, 24h urine output, liver and kidney function, electrolytes and so on. The above results confirmed that domestic made of pterygium testosterone is an effective drug to promote cervical maturation.