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COX-2是一种双功能酶,兼有环氧合酶活性和氢过氧化酶活性。COX-2与肿瘤的关系日益被重视,本文就COX-2的生物学特性及其在肿瘤发生、发展中的作用,尤其在头颈部肿瘤中的作用综述如下。1COX生物学特性COX-1基因位于染色体9q32-q33.3上,全长22.5kb,COX-2基因位于染色体1q25.2-25.3
COX-2 is a bifunctional enzyme with both cyclooxygenase activity and hydroperoxidase activity. The relationship between COX-2 and tumor is increasingly valued. This article summarizes the biological characteristics of COX-2 and its role in tumorigenesis and development, especially in head and neck cancers. 1 COX Biological Characteristics The COX-1 gene is located on chromosome 9q32-q33.3 and is 22.5 kb in length. The COX-2 gene is located on chromosome 1q25.2-25.3.