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氮(艹卓)脒青霉素(Mecillinam,MPC)系一种具新型结构的半合成脒基青霉素。与其他青霉素或半合成青霉素不同,它的抗菌谱较窄,对革兰氏阴性菌,特别是大肠杆菌和伤寒杆菌的作用更为突出。临床治疗尿路感染、细菌性痢疾和伤寒有明显效果。抗菌作用MPC对大肠杆菌、阴沟杆菌、肺炎杆菌、沙门氏菌、痢疾杆菌及某些沙雷氏菌株有高度抗菌活性,尤对大肠杆菌作用见强,为其他内酰胺抗生素所不及,最低抑菌浓度(MIC)<0.05μg/ml;对沙门氏菌的MIC为0.5～0.05mg/L;肺炎杆菌和克雷勃氏菌对MPC的敏感范围是0.39～>100mg/L,变形杆菌的敏感范围较窄,50%能被本品0.1μg/ml所抑制;对革兰氏阳性菌,如葡萄球菌、链球菌作用差;粪链球菌和绿脓杆菌对本品耐药。
Mecillinam (MPC) is a semisynthetic amidine penicillin with a novel structure. Unlike other penicillins or semi-synthetic penicillins, its antibacterial spectrum is narrower and more pronounced for Gram-negative bacteria, especially Escherichia coli and Salmonella typhi. Clinical treatment of urinary tract infection, bacillary dysentery and typhoid have obvious effects. Antibacterial activity MPC on Escherichia coli, bacilli, Klebsiella pneumoniae, Salmonella, Shigella and some Serratia strains have a high degree of antibacterial activity, especially against Escherichia coli strong, less than other lactam antibiotics, the minimum inhibitory concentration ( MIC) <0.05μg / ml; Salmonella MIC of 0.5 ~ 0.05mg / L; Klebsiella pneumoniae and Klebsiella on MPC sensitivity range of 0.39 ~> 100mg / L, Proteus sensitive range is narrow, 50 % Can be inhibited by this product 0.1μg / ml; Gram-positive bacteria, such as staphylococcus, streptococcus poor; Streptococcus faecalis and Pseudomonas aeruginosa resistance to the goods.