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目的：对Ⅱ型糖尿病（ＮＩＤＤＭ）并发急性脑梗死（ＡＣＩ）的中风证候特征与神经内分泌免疫网络（ＮＥＩＮ）及其相应脑病理改变进行观察研究，以从宏观与微观辨证阐明该病的发病机理。方法：采用中风辨证量表、血液流变学等指标对脑卒中患者始发状态进行评分和放射免疫分析，包括下丘脑－垂体－肾上腺轴（ＨＰＡ）激素（促肾上腺皮质激素释放激素、促肾上腺皮质激素、皮质醇）与免疫细胞因子（肿瘤坏死因子α、白细胞介素－６）水平变化等，并与正常体检者进行对照。结果：本观察中风证型以风火阳亢证型组ＨＰＡ轴激素及免疫细胞因子失常最为显著，其血中含量与风痰瘀阻证组及气虚血瘀证组相比，均具有非常重要的统计学意义（Ｐ＜０．０１～０．００１），后两组证型与正常健康组比较也获同样结果（Ｐ＜０．０５～０．００１）。结论：Ⅱ型糖尿病并发急性脑梗死中医证型与神经内分泌免疫网络关系密切，深入研究其变化，将有助于阐明该病的发病机理和提高其微观辨证的诊断水平。
Objective: To observe the characteristics of stroke syndrome and neuroendocrine-immune network (NEIN) and their corresponding brain pathological changes in type 2 diabetes mellitus (NIDDM) complicated with acute cerebral infarction (ACI) mechanism. Methods: The onset status of stroke patients was scored and radioimmunoassay was performed using the Syndrome Differentiation Scale, Hemorheology and other indicators, including hypothalamic-pituitary-adrenal axis (HPA) hormones (corticotropin-releasing hormone, adrenal gland Corticosteroids, cortisol) and immune cytokines (tumor necrosis factor alpha, interleukin-6) levels, and compared with normal subjects were controlled. Results: The observation of stroke syndrome type wind yin hyperactivity HPA axis hormones and immune cytokine disorders most significant, and its blood levels and phlegm and blood stasis syndrome group compared Qi, are very important (P <0.01 ~ 0.001). The latter two groups also got the same result (P <0.05 ~ 0.001) compared with normal group. CONCLUSION: The TCM syndromes of type II diabetes mellitus complicated with acute cerebral infarction are closely related to the neuroendocrine immune network, and in-depth study of the changes will help clarify the pathogenesis of the disease and improve its diagnostic value of microcosmic syndrome differentiation.