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目的小剂量咪唑安定对60岁以上的老年患者进行支气管镜检查的镇静效果观察。方法采用双盲前瞻性对照研究,对60岁以上的老年气管镜检查患者随机分生理盐水对照组、0.05mg/kg剂量和、0.1mg/kg剂量咪唑安定组进行干预,并对检查中心率、呼吸频率、神志、咳嗽排痰指令的响应、2分钟内进入声门例数、术后随访痛苦程度等内容进行对比分析。结果较低剂量的咪唑安定与生理盐水对照组比较,在操作早期具有足够的镇静作用,可抑制镜子通过声门的刺激反应对心率、呼吸频率的影响(P<0.05);与高剂量的咪唑安定组比较,操作的中后期也具有较好的咳痰响应和快速完全清醒、近事遗忘效应(P<0.05)。结论小剂量咪唑安定对60岁以上的老年患者进行气管镜检查的镇静效果良好,有实用意义。
Objective To observe the sedative effect of low dose midazolam for bronchoscopy in elderly patients over the age of 60 years. Methods A double-blind, prospective, controlled study was conducted in elderly patients over 60 years of age with bronchoscopy randomly divided into normal saline control group, 0.05mg / kg dose and 0.1mg / kg dose of midazolam group intervention, and check the center rate, Respiratory rate, consciousness, response to cough and expectoration instructions, number of cases of glottic entry in 2 minutes, degree of pain after follow-up, etc. were analyzed comparatively. Results Compared with the saline control group, the lower dose of midazolam had sufficient sedation at the early stage of operation, which could inhibit the influence of the mirror on the heart rate and respiratory rate (P <0.05) Diazepam group, the operation of mid and late also have better expectoration response and rapid and complete awake, the recent forgetting effect (P <0.05). Conclusions Small-dose midazolam has a good sedative effect on bronchoscopy in elderly patients over the age of 60, which is of practical significance.