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1974年由 Reynolds、Newball 开创支气管肺泡灌洗术(BAL),作为肺的炎症及免疫过程的窗口或肺的液性活检,开始以阐明肺疾患,特别是结节病、过敏性肺炎(HP)、特发性间质性肺炎(IPF)等弥漫性肺疾患的病理生理为主要目的。八十年代有关各种疾病通过 BALF 得到的液性或细胞成分的知识增加,特别是由于以单克隆抗体能鉴别淋巴细胞亚型,提高了 BAL 在诊断和治疗上的临床意
Bronchoalveolar lavage (BAL) was initiated by Reynolds, Newball in 1974 as a window of the inflammation and immunization of the lungs or a liquid biopsy of the lungs to elucidate lung conditions, especially sarcoidosis, hypersensitivity pneumonitis (HP) , Idiopathic interstitial pneumonia (IPF) and other diffuse lung disease pathophysiology for the main purpose. The increased knowledge of the fluid or cellular components obtained from BALF in various diseases in the 1980s and in particular the increased clinical utility of BAL in diagnosis and treatment due to the identification of lymphocyte subtypes with monoclonal antibodies