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本工作观察P物质对蟾蜍脊髓反射放电的影响。制备在体的背面纵切脊髓标本,于已分离的最后一节背根未切断中枢端施加单脉冲电刺激,在同节同侧腹根记录脊髓反射放电,观察在脊髓背表面施加P物质及此后的脊髓反射电位。实验观察到用单脉冲电刺激背根时在腹根记录出多突触反射电位,其平均幅度为456.25±26.5μV,平均发放时程为43.5±3.4ms,施加P物质后反射电位幅度增强,10min时增强到605.36±34.78μV;发放时程延长,10min时延长到68.29±8.89ms,与施加P物质前比较均具有非常显著差异。上述结果表明P物质可增强脊髓反射放电,提示P物质对脊髓具有兴奋作用,作者等推测这可能系脊髓神经元在P物质影响下对刺激背根的兴奋性反应增强所致。
This work observed the substance P on the toad spinal cord reflex discharge. The longitudinal spinal cord specimens were prepared on the back of the body. One-pulse electrical stimulation was applied to the unselected central part of the dorsal root in the last section. The spinal cord reflex discharges were recorded on the same side of the same abdomen. After the spinal cord reflex potential. The experimental results showed that when the dorsal root was stimulated by a single pulse, the synaptic reflex potential was recorded in the ventral root. The average amplitude was 456.25 ± 26.5μV and the average release duration was 43.5 ± 3.4ms. After the substance P was applied, the amplitude of the reflex potential increased, Increased to 605.36 ± 34.78μV at 10min. The duration of delivery was extended to 68.29 ± 8.89ms at 10min, which was significantly different from that before application of substance P. The above results show that substance P can enhance the reflex discharge of the spinal cord, suggesting that substance P has an excitatory effect on the spinal cord. The authors speculate that this may be due to the enhancement of the excitatory response of the spinal cord neurons to the dorsal root under the influence of Substance P.