论文部分内容阅读
目的:观察匹多莫德联合曲安奈德治疗口腔扁平苔藓的疗效和安全性。方法:回顾性分析60例口腔扁平苔藓患者资料,按用药的不同分为观察组(35例)和对照组(25例)。对照组患者给予曲安奈德注射液1 ml+2%利多卡因注射液1 ml混合,根据病损大小在局部病损区涂擦,3次/日;观察组患者在对照组治疗的基础上给予匹多莫德分散片800 mg,两餐间服用,2次/日,连用2周后,改为800 mg,口服,1次/日。两组患者疗效均为4周。观察两组患者的临床疗效,并随访用药1、3个月后的疗效及不良反应发生情况。结果:治疗1、3个月后,观察组患者总有效率均显著高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论 :匹多莫德联合曲安奈德治疗口腔扁平苔藓较单用曲安奈德疗效更显著,安全性较好。
Objective: To observe the efficacy and safety of pidotimod and triamcinolone acetonide in the treatment of oral lichen planus. Methods: The data of 60 patients with oral lichen planus were retrospectively analyzed. The patients were divided into the observation group (35 cases) and the control group (25 cases) according to the different drugs. Patients in the control group were given 1 ml of triamcinolone acetonide injection 1% and lidocaine injection 2%, and then were rubbed in the local lesion area according to the lesion size 3 times a day. On the basis of the treatment of the control group, Pidopimag dispersible tablets 800 mg, two meals per day, 2 times / day, once every 2 weeks, changed to 800 mg, orally, 1 time / day. Two groups of patients were 4 weeks. To observe the clinical efficacy of two groups of patients, and follow-up treatment of 1,3 months after the efficacy and adverse reactions. Results: After 1 and 3 months of treatment, the total effective rate in the observation group was significantly higher than that in the control group, with statistical significance (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion: Pidotimod combined with triamcinolone acetonide in the treatment of oral lichen planus is more effective and more safe than triamcinolone acetonide alone.