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目的：评价纳美芬对儿童脊柱侧弯矫形术术中唤醒试验的影响。方法选择年龄在8～14岁脊柱侧弯患儿50例，ASAⅠ～Ⅱ级。将患儿随机分为2组，舒芬太尼组（S组25例）和纳美芬＋舒芬太尼组（NS组25例）。两组患儿均采用舒芬太尼、丙泊酚和罗库溴铵快速诱导插管， NS组诱导后静脉给予纳美芬0．2μg/kg，术中均以吸入七氟醚和泵注瑞芬太尼、丙泊酚维持麻醉。唤醒试验前依次停止吸入七氟醚及静脉麻醉药，待自主呼吸恢复后开始进行唤醒试验，记录两组患儿入室时（T0）、诱导后（T1）、手术开始时（T2）、七氟醚停止吸入时（T3）、唤醒试验开始时（T4）、唤醒试验开始后5 min（T5）、唤醒试验开始后10 min（T6）、唤醒试验结束前（T7）的心率（HR）、平均动脉压（MAP）、脑电双频指数BIS值；记录停止麻醉药物到唤醒试验成功时间；记录患儿对指令的配合程度（唤醒质量）。结果与S组相比，NS组患儿在唤醒试验过程中MAP明显降低（P＜0．05），呛咳和躁动的发生率降低。结论纳美芬用于儿童脊柱侧弯矫形术有助于维持术中唤醒试验时血流动力学的稳定，提高唤醒质量，不影响唤醒时间，具有良好的保护效应。“,”Objective To evaluate the effect of nalmefene on intraoperative wake-up test in chil-dren undergoing scoliosis surgery.Methods Fifty ASAⅠ~Ⅱ children,aged 8 ~14 yr,scheduled for e-lective scoliosis surgery,were randomly divided into 2 groups(n=25 each):sufentanil group(group S)and nalmefene combined with sufentanil group(group NS).Rapid induction and intubation were induced with sufentanil,propofol and rocuronium,and maintained with inhalation of sevoflurane combined with infusion of remifentanil and propofol in both groups.In group NS,0.2 μg/kg of nalmefene was infused after anes-thesia induction.Before the wake-up test,inhalation of sevoflurane and infusion of remifentanil and propofol were stopped in turn.The wake-up test was performed when the children were breathing spontaneously. Mean arterial pressure(MAP),heart rate(HR)and bispectral index(BIS)were recorded before anesthesia induction(T0 ),after anesthesia induction(T1 ),at the beginning of operation(T2 ),after the sevoflurane in-halation stopped(T3 ),at the beginning of wake-up test(T4 ),5 min after the wake-up test(T5 ),10 min af-ter the wake-up test(T6 )and at the end of wake-up test(T7 ).Results During the wake-up test,the MAP level and incidence of bucking and restlessness in the group NS were significantly lower than those in the group S(P<0.05).Conclusion For children undergoing scoliosis surgery,nalmefene is helpful in main-taining haemodynamic stability during the wake-up test.It has good protective effects on improving the quality without affecting wake-up time.