硫化氢(hydrogen sulfide,H_2S),继一氧化氮(ni-trogen monoxidum,NO)和一氧化碳(carbon monox-ide,CO)之后新近发现的第3号内源性气体信号分子,是气体信号分子家族的新成员,人类认识和研究其作用已有近300年历史。数百年来,人们普遍认为H_2S 是工业生产中产生的有害气体。直到上世纪90年代中后期人们发现哺乳动物体内半胱氨酸代谢可生成 H_2S,其生理作用的重要性随后才逐步得到研究人员的重视。鉴于在血管平滑肌细胞中的重要性, Hydrogen sulfide (H2S), followed by nitric oxide (ni-trogen monoxidum, NO) and carbon monoxide (carbon monox-ide, CO) recently discovered No. 3 endogenous gas signal molecules, is a family of gas signal molecules Nearly 300 years of human cognition and research have been made. For hundreds of years, H 2 S has generally been considered a noxious gas produced in industrial processes. Until the late 90s of last century, people found that mammalian cysteine ​​metabolism can generate H_2S, the importance of its physiological role and then gradually get the researchers attention. Given the importance in vascular smooth muscle cells,