论文部分内容阅读
免疫球蛋白(Ig)和T-细胞受体(TCR)基因重排是检测淋巴系统增殖性疾病克隆性的灵敏方法。已经证明了Ig重链TCRβ和γ基因探针对急性白血病缺乏谱系特异性,而传统认为Ig轻链基因重排是B—细胞谱系的一项很特异的指标。本文报道了1例T-细胞急性淋巴细胞白血病(ALL)患者,其TCRβ链基因发生重排,意外的是Igκ轻链基因也发生重排,未发现Ig重链基因重排。其中T-细胞ALL的κ轻链基因重排尚属首例报道。
Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements are sensitive methods for detecting clonality in lymphoproliferative diseases. It has been demonstrated that Ig heavy chain TCR beta and gamma gene probes lack lineage specificity for acute leukemia, whereas Ig light chain gene rearrangement is traditionally considered a very specific indicator of B-cell lineage. In this paper, we report the rearrangement of TCR β chain gene in one case of T-cell acute lymphoblastic leukemia (ALL). Surprisingly, rearrangements of Ig kappa light chain gene were also found, and Ig heavy chain gene rearrangement was not found. T-cell ALL kappa light chain gene rearrangement is the first report.