论文部分内容阅读
目的观察川崎病(KD)患儿血清降钙素原(PCT)、白介素-6(IL-6)水平的变化,探讨其与KD并发症间的关系。方法研究对象为2003-10—2005-12在首都儿科研究所附属儿童医院住院的88例KD患儿,测定其血清PCT、IL-6水平;正常对照为同期33例健康儿童,进行同样检测。结果(1)71例急性期患儿PCT水平与14例亚急性期患儿、33例正常对照儿童PCT水平相比,其差异均有统计学意义(P<0.05和<0.01)。(2)急性期24例其他系统并发症患儿PCT水平显著高于47例无其他系统并发症患儿,且差异有统计学意义(P<0.01);当PCT≤0.5ng/mL时,其他系统并发症发生率16.3%;当PCT>0.5时,其他系统并发症发生率41.0%,两者差异有统计学意义(P<0.05)。(3)56例急性期患儿IL-6水平与11例亚急性期患儿、14例正常对照儿童IL-6水平相比,其差异均有统计学意义(P值均<0.01)。(4)急性期17例其他系统并发症患儿IL-6水平显著高于39例无其他系统并发症患儿IL-6水平,二者差异有统计学意义(P<0.01)。结论(1)KD患儿急性期血清PCT、IL-6水平增高,亚急性期下降,PCT增高维持时间较IL-6稍长。(2)血清PCT、IL-6水平在发生其他系统并发症患儿中是显著升高的,对其检测有助于KD的病情评价。
Objective To observe the changes of serum procalcitonin (PCT) and interleukin-6 (IL-6) levels in children with Kawasaki disease (KD) and to explore their relationship with KD complications. Method Subjects were 88 cases of KD 2003-10-2005-12 at Children’s Hospital of Capital Institute of Pediatrics hospitalization, measured serum PCT, IL-6 levels; normal control for the same period 33 cases of healthy children, the same test. Results (1) The PCT level in 71 children with acute stage was significantly higher than that in 14 children with subacute stage and 33 normal controls (P <0.05 and <0.01). (2) 24 cases of acute complications in children with other PCT complications was significantly higher than in children 47 cases no other systems, there were statistically significant (P <0.01) difference; when PCT≤0.5ng / mL, the other The incidence of systemic complications was 16.3%. The incidence of other systemic complications was 41.0% when PCT> 0.5. The difference was statistically significant (P <0.05). Children with acute (3) 56 cases of IL-6 levels, as compared to normal controls IL-6 levels in children of children and subacute 11 cases 14 cases, the differences were statistically significant (P <0.01). (4) IL-6 in the acute phase in children with 17 cases of other complications was significantly higher than IL-6 levels in children with no other complications of 39 patients was statistically significant (P <0.01) difference between them. Conclusions (1) The serum levels of PCT and IL-6 in acute KD children are increased, the subacute phase is decreased, and the increase of PCT is longer than IL-6 in children with KD. (2) Serum PCT, IL-6 levels were significantly increased in children with other systemic complications, and its detection could be helpful for the evaluation of KD.