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提出一种原位交联工艺,用于一步制备交联明胶电纺纤维膜,克服目前该电纺膜交联工艺繁琐以及交联过程破坏纤维形态等缺点.通过一系列实验,找出明胶-三氟乙醇-戊二醛三元溶液体系的稳定电纺条件.所得的纤维直径在1μm左右,远大于单纺明胶的纤维直径.同时发现,在电纺过程中,由于纤维表面戊二醛迅速挥发,使得纤维形成“伪核壳”结构.利用流变仪对三元溶液交联速率进行分析,结果表明戊二醛加入明胶溶液后,体系黏度瞬间增大,10 min后维持稳定.最后,通过耐水性试验评价纤维膜交联效果,发现纤维膜有10%左右的溶解,但在水介质中仍可保持很好的纤维形态.
In this paper, an in-situ cross-linking process is proposed for the preparation of cross-linked gelatin electrospun fiber membrane in one step, to overcome the shortcomings of the current cross-linking process of the electrospun membrane and the destruction of the fiber morphology during the cross-linking process.A series of experiments show that gelatin- Trifluoroethanol - glutaraldehyde ternary solution system of the stability of the electrospinning conditions obtained fiber diameter of about 1μm, much larger than the single-spun gelatin fiber diameter was also found that in the electrospinning process, the fiber surface glutaraldehyde rapidly The results showed that the viscosity of glutaraldehyde increased instantaneously after gelatin solution was added, and remained stable after 10 min. Finally, the cross-linking effect of the fiber membrane was evaluated by the water resistance test. It was found that the fiber membrane was dissolved by about 10%, but the fiber morphology was still maintained in the aqueous medium.